Consieve UFC RC TFF Cassettes - Process

Consieve UFC tangential flow filtration cassette is made of RC (Regenerated Cellulose) membrane, which provides extra low protein bindings and wide chemical compatibility. It can be compatible with organic solutions as well. Which make it suitable for ultrafiltration of various biological products such as antibodies, recombinant proteins, and blood product, etc. The cassette is easy to clean, install and has a high retention efficiency, with low working volume and high efficiency which ensures product yields.

Consieve UFC Ultrafiltration cassettes are available in a wide range of molecular weight cut-offs from 1 kDa to 300 kDA. It can be easily scale-up from Lab, Pilot to Process scale with a wide volume range from 0.5L to 20,000L. They are widely used in separation, concentration and diafiltration in downstream bioprocessing.

The cassettes should be used with our Ultrafiltration Cassette Stainless Steel Holder:

EFA 0.01m² or 0.02m² cassettes use with Ultrafiltration Cassette Holders (0.01m²)

EFA 0.11m² cassettes use with Ultrafiltration Cassette Holders (0.11m²)

EFA 0.5m²or 2.5m²cassettes use with Ultrafiltration Cassette Holders (0.5m²)

Standard Coarse Screen:

Generates moderate turbulence on the membrane surface, reducing clogging. Standard Coarse Screen requires a higher inlet flow rate to match the appropriate tangential flow velocity. The pressure drop (dp) is significantly lower compared to Tight Screens. Standard coarse screen cassettes are suitable for clarified samples with medium to high viscosity.

Suspended Screen:

Generates the weakest turbulence and low shear force on the surface, but still significantly reduces clogging. Theoretically, Suspended Screen requires a very high inlet flow rate. Due to its open screen structure, it can accommodate more particles (cells, cell debris) without clogging. Suspended screen cassettes are suitable for unclarified samples with high particle content or high viscosity, and samples that are sensitive to shear force.